Caltech’s PhD in Biochemistry and Molecular Biophysics trains students to push the boundaries of life sciences through computational and experimental techniques. Below are suggested dissertation topics.
Computational Analysis of Protein Folding Mechanisms
Molecular Dynamics Simulations of Membrane Proteins
Cryo-EM and X-ray Crystallography in Structural Biology
Enzyme Mechanisms: Understanding Catalysis at the Atomic Level
Single-Molecule Biophysics: Techniques and Applications
Computational Tools for Predicting Protein-Protein Interactions
Design and Engineering of Protein Nanostructures
Molecular Simulations of Drug-Receptor Binding
Understanding Allosteric Regulation in Multi-Subunit Proteins
Structural Basis of Disease-Causing Mutations in Protein Complexes
Mechanisms of Protein Aggregation in Neurodegenerative Diseases
Biophysical Characterization of Nucleic Acid-Protein Interactions
Designing Artificial Enzymes for Biocatalysis
High-Throughput Screening of Small Molecule Inhibitors for Cancer Therapy
Modeling the Interactions Between DNA and Chromatin
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