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Dissertation Topics for Ph.D. in Quantitative & Computational Biology

Use data, mathematics, and modeling to drive discoveries in genomics, systems biology, and biomedical computation at Princeton.

🧬 Introduction

Princeton’s Ph.D. in Quantitative and Computational Biology (QCB) equips students to tackle the complexity of biological systems through quantitative frameworks, bioinformatics, and computational tools. Below are curated research topics that span the intersections of data science, biology, and advanced modeling.

📘 Suggested Dissertation & Research Topics

Network Inference of Gene Regulatory Circuits in Developmental Systems

Single-Cell RNA-Seq Data Analysis for Cell Lineage Mapping

Machine Learning Approaches for Protein-Protein Interaction Prediction

Stochastic Modeling of Intracellular Reaction Networks

Quantitative Modeling of Immune Response Dynamics

Spatiotemporal Analysis of Cell Migration in Cancer Metastasis

Bioinformatic Pipelines for Structural Variant Detection in Genomes

Evolutionary Dynamics Simulations of Microbial Populations

Multi-Omics Integration for Personalized Medicine Applications

High-Throughput CRISPR Screening Data Interpretation

Comparative Genomics for Phylogenetic Reconstruction

Probabilistic Graphical Models in Gene Expression Analysis

Synthetic Biology Circuits: Predictive Design and Simulation

Mathematical Models of Circadian Rhythms in Mammals

Computational Neuroscience of Sensory Encoding Mechanisms

Simulation of Biochemical Pathways Using Kinetic Monte Carlo Methods

Deep Learning for Histopathological Image Classification

Bayesian Inference in Epidemiological Modeling

Population Genetics and Coalescent Theory with Big Data

Quantitative Trait Loci Mapping in Complex Traits

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Collexa supports Ph.D. students in QCB with statistical genomics, algorithm development, high-dimensional data processing, reproducible pipelines, and visualizations for scholarly publications.

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