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Project Ideas for Doctor of Philosophy in Biological Sciences

Decode life’s complexity from molecules to ecosystems.

🏛 Introduction

CMU’s Biological Sciences PhD blends single-cell multi-omics, synthetic ecology, and computational evolution. Rotations span cryo-EM of ribosome assembly, AI-driven drug discovery for neglected diseases, and field genomics tracking climate-driven species migration. Professional development in science diplomacy and biotech entrepreneurship equips graduates to influence both policy and industry innovation.

💡 Suggested Project Titles

CRISPR base-editing screen mapping antibiotic-resistance epistasis

Long-read metagenomics uncovering plastic-degrading microbiome enzymes

Single-cell ATAC-seq atlas of brain aging in murine models

Agent-based simulation of coral-reef microbiome shifts under heat stress

Protein language-model generative design of antiviral peptides

eDNA monitoring pipeline for endangered amphibian population dynamics

Synthetic quorum-sensing circuit regulating bio-plastic synthesis in E. coli

Phylo-geographic analysis of zoonotic spillover using Bayesian skyline plots

Deep-learning model predicting RNA splicing aberrations from variant data

Optogenetic control of plant stomata for drought-tolerance studies

Citizen-science mobile app crowdsourcing invasive-species sightings

Comparative epigenomics of diapause in overwintering insect species

Bio-orthogonal labeling approach tracking gut-microbiota metabolite flow

Machine-vision quantification of pollinator behavior in urban gardens

Policy memo on global biodiversity data sharing and Indigenous rights

Public outreach VR exhibit illustrating cell-division checkpoints

Carnegie Mellon – PhD in Biological Sciences

Advance life-science discovery and impact at CMU.

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