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Project Ideas for Doctor of Philosophy in Quantitative Biosciences

Apply mathematics, computation, and physics to decipher living systems.

🏛 Introduction

CMU’s PhD in Quantitative Biosciences equips scientists to unite theory and high-dimensional data for breakthroughs in health, ecology, and evolution. Doctoral students model stochastic gene-expression, develop physics-informed neural networks to predict protein folding, and deploy Bayesian epidemiological models during real-time outbreaks. Cross-training in machine learning, micro-fluidics, and policy ensures graduates can both derive equations and deploy solutions in clinics or conservation field sites.

💡 Suggested Project Titles

Single-cell multi-omics integration algorithm revealing lineage decisions in hematopoiesis

Stochastic differential-equation model of CRISPR gene-drive dynamics in wild populations

Physics-guided graph neural network predicting conformational ensembles of IDPs

Agent-based model simulating tumor-immune co-evolution under checkpoint therapy

Information-theoretic analysis of neural coding in olfactory circuits

Deep-learning enhancer–promoter interaction predictor using chromatin-contact maps

Optimal experimental-design framework selecting perturbations in synthetic biology

Eco-evolutionary game theory explaining microbial community metabolite exchange

Bayesian change-point detection of zoonotic-spillover events from surveillance data

Nanopore signal deconvolution tool improving detection of base modifications

Biomechanical model linking cell-shape changes to tissue morphogenesis forces

Multi-scale simulation of carbon-fixation pathways in engineered cyanobacteria

Epidemic-forecast ensemble leveraging mobile-device mobility networks

Genome-wide association meta-analysis pipeline for rare disease consortia

Policy brief on genomic data-sharing frameworks balancing privacy and innovation

Citizen-science platform gamifying annotation of 3-D cell-tracking datasets

Quantum-inspired annealing heuristic for protein-design energy landscapes

Synthetic-ecology micro-fluidic chip studying predator–prey oscillations

Explainable AI model of antimicrobial-resistance gene transfer in hospitals

Interactive VR tool teaching principles of stochastic gene networks to undergrads

Carnegie Mellon – PhD in Quantitative Biosciences

Decode complex biology with mathematics, computing, and innovation at CMU.

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