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Project Ideas for Doctor of Philosophy in Biochemistry

Molecular discovery driving health, energy, and synthetic biology advances.

🏛 Introduction

UIUC’s Biochemistry PhD leverages cryo-EM, single-molecule spectroscopy, and deep mutational scanning to unravel life’s chemistry. Students evolve thermostable enzymes for carbon capture, map chromatin architecture with Hi-C, and design optogenetic switches for cellular therapeutics. Cross-disciplinary institutes fuel translational impact.

💡 Suggested Project Titles

Allosteric regulation mapping via multi-site saturation mutagenesis

Time-resolved cryo-EM snapshots of ribosome rescue factors

Photocaged CRISPR guide RNAs enabling spatiotemporal editing

Synthetic metabolic pathway sequestering CO₂ into bioplastics

High-throughput screening for inhibitors of viral proteases

Single-molecule FRET study of telomerase processivity

Computational design of protein-protein interaction disruptors

Grant proposal for AI-driven antibiotic discovery pipeline

Hydrogenase mimetics for bio-hydrogen fuel cells

Optogenetic regulation of CAR-T cell activation kinetics

Epigenomic profiling of famine-induced transgenerational marks

White paper on ethical dual-use of gene synthesis technologies

Podcast interviewing pioneers of cryo-EM resolution revolution

University of Illinois – PhD in Biochemistry

Discover and engineer life’s machinery with UIUC.

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