Northwestern’s Biochemistry PhD trains scientists to decode life at atomic resolution. Students determine cryo-EM structures of membrane transporters, track intracellular signaling with single-molecule FRET, and design CRISPR base editors to correct disease mutations. Interdisciplinary cores with Chemistry and Biomedical Engineering foster translational pipelines from bench discovery to biotech spin-outs.
Resolve high-resolution structure of SARS-CoV-2 polymerase-drug complex
Engineer thermostable Cas12 enzymes for point-of-care diagnostics
Characterize phase-separation dynamics of neurodegenerative prion proteins
Develop fluorogenic probes quantifying ROS flux in live cardiomyocytes
Map metabolic cross-talk between tumor-associated macrophages and cancer cells
Screen small-molecule libraries for inhibitors of antibiotic-resistance enzymes
Study ribosome stalling mechanisms via cryo-EM and ribosome profiling
Design optogenetic allosteric switches controlling kinase activity
Investigate lipid-protein interactions in mitochondrial contact-site complexes
Quantify single-enzyme turnover heterogeneity with nano-fluidics
Model directed-evolution fitness landscapes using deep mutational scanning
Create AI pipelines predicting antigen-antibody binding affinities
Elucidate glycosyltransferase specificity by comparative X-ray crystallography
Develop cell-free biosynthesis of rare natural-product antibiotics
Write a translational grant proposal for enzyme-replacement therapy in orphan disease
Unravel molecular mysteries and drive therapeutic discovery with Northwestern Biochemistry.
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