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Project Ideas for Doctor of Philosophy in Biochemistry

Discover molecular solutions to biological challenges through advanced biochemical research.

🏛 Introduction

UMD’s PhD in Biochemistry offers students an immersive research experience in protein chemistry, structural biology, metabolism, and cellular mechanisms. Students collaborate across biomedical and chemical sciences, using tools like spectroscopy, crystallography, and computational modeling.

💡 Suggested Project Titles

Structural elucidation of cancer-linked protein complexes via X-ray crystallography

Directed evolution of enzymes for industrial biocatalysis

Analysis of lipid metabolism pathways in metabolic disorders

Fluorescence-based study of conformational changes in membrane proteins

CRISPR-mediated investigation of gene regulation in yeast models

Kinetic characterization of enzymes involved in DNA repair

Design of synthetic pathways for bio-based pharmaceutical precursors

Single-molecule FRET analysis of protein folding dynamics

Study of redox regulation in neurodegenerative disease proteins

Development of biosensors for detection of endocrine disruptors

NMR-based mapping of ligand binding in antibiotic target proteins

Investigation of phase separation in nuclear pore proteins

Structure-function relationship studies of metalloproteins

Computational modeling of enzyme-substrate docking interactions

Design of inhibitor libraries for protease-related drug discovery

Study of viral protein-host interactions in immune suppression

Photoaffinity labeling for active site mapping in oxidoreductases

Biochemical profiling of stress response in extremophilic organisms

Time-resolved spectroscopy of electron transport in thylakoid membranes

Synthetic peptide design for structural mimicry of natural proteins

University of Maryland – PhD in Biochemistry

Contribute to molecular discovery through research in protein structure, cellular chemistry, and biochemical innovation in UMD’s Biochemistry PhD.

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