Harvard’s Chemical Biology PhD unites synthetic chemistry, structural biology, and cellular imaging to reveal how molecular interactions govern physiology and disease. Doctoral researchers design clickable probes that map epigenetic marks in live neurons, evolve enzymes for carbon‑negative plastics, and mine microbial genomes for antibiotic scaffolds. Cross‑appointments at the Broad Institute, Dana‑Farber, and HMS accelerate translation of bench discoveries into clinical pipelines and venture‑backed start‑ups.
Bio‑orthogonal probe mapping protein glycation in diabetic tissue
Directed evolution of PET‑degrading enzymes under UV stress
CRISPR‑based screen identifying lipid‑metabolism drug targets
Allosteric inhibitor design for bromodomain epigenetic readers
Single‑cell metabolomics of chemotherapy‑resistant leukemia clones
Photocaged antibiotics activated by tumor micro‑environment light
Nanobody conjugates delivering siRNA across the blood–brain barrier
Mass‑spectrometry workflow profiling on‑target covalent fragment hits
High‑throughput selection of oxygen‑tolerant nitrogenase variants
AI model predicting PROTAC ternary‑complex stability
Microfluidic platform evolving biosynthetic pathways for alkaloids
Ethics brief on dual‑use chemical‑genetics research
Citizen‑science program sampling soil for novel polyketides
Visualization tool of reactive oxygen species in live cardiomyocytes
Policy memo on accelerating antibiotic approval pathways
Fuse chemistry and biology to unlock next‑generation medicines.
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