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Project Ideas for Doctor of Philosophy in Medical Sciences

Bridge basic discovery and clinical insight to improve human health.

🏛 Introduction

Harvard’s Medical Sciences PhD integrates HMS bench labs with hospital clinical contexts, training physician-scientists and PhDs to decode disease mechanisms—from epigenomic oncology to cardio-metabolic signaling. Students shadow clinicians, design translational trials, and commercialize diagnostics through the Blavatnik accelerator.

💡 Suggested Project Titles

Single-cell multi-omics of tumor immune evasion pathways

CRISPR knock-in disease models in humanized mice

Metabolomic signature predicting heart-failure readmission

Liquid-biopsy assay for minimal residual disease detection

AI-augmented pathology pipeline for rare pediatric tumors

Thesis on microbiome mediation of immunotherapy toxicity

Drug-repurposing screen targeting fibrosis signaling nodes

Wearable biosensor validating arrhythmia prediction algorithms

Policy brief on insurance coverage for genomic diagnostics

Ethics study of return-of-results in multi-omics trials

Community health partnership deploying rapid TB diagnostics

Open-source database of drug-gene interaction phenotypes

Workshop training clinicians in R for precision medicine

Podcast featuring physician-scientist career journeys

Interactive patient-education tool on genomic testing literacy

Harvard – PhD in Medical Sciences

Transform bedside questions into bench breakthroughs—and back again.

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