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Project Ideas for Doctor of Philosophy in Systems Biology

Integrate computation and experimentation to model living systems.

🏛 Introduction

Harvard’s Systems Biology PhD unites physicists, engineers, and biologists to decode emergent behaviors in cells and ecosystems. Students build microfluidic chemostats, simulate gene networks with agent-based models, and harness single-cell sequencing to map developmental trajectories, launching breakthroughs in synthetic biology and precision medicine.

💡 Suggested Project Titles

Live-cell imaging and modeling of oscillatory p53 dynamics

CRISPR bar-coding tracing lineage in organoid development

Agent-based simulation of gut microbiome spatial ecology

Design of synthetic toggle switches with reduced noise

Metabolic-flux analysis under nutrient cycling conditions

Machine-learning predictor of protein phase-separation propensity

Thesis on ecological stability in microbial consortia bioreactors

Ethics paper on biosafety in gene-drive population control

Open-source dashboard visualizing multi-omics trajectories

Podcast featuring systems-biology start-up founders

Harvard – PhD in Systems Biology

Model, predict, and engineer complex biological networks.

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