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Project Ideas for Doctor of Philosophy in Molecular and Cellular Biology

Dissect cellular machinery to unveil life’s fundamental rules.

🏛 Introduction

Harvard’s MCB PhD immerses researchers in CRISPR genome editing, cryo-ET of organelles, and optogenetic control of cell signaling. Trainees bridge physics, computation, and chemistry to visualize, model, and rewire cellular processes underlying development and disease.

💡 Suggested Project Titles

Optogenetic toolkit modulating phase-separated condensates

Cryo-electron tomography of mitochondrial contact sites

Live-cell biosensors tracking kinase gradients during migration

Genome-wide CRISPRi screen mapping autophagy regulators

Single-molecule FRET of transcription-factor binding kinetics

AI-based segmentation of 3-D cell cultures in light-sheet data

BioID proximity labeling of synaptic vesicle proteins

Thesis on mechano-transduction pathways in cancer invasion

Ethics paper on dual-use concerns in gene-drive technology

Open-source workflow for FAIR sharing of cell-imaging datasets

Public outreach video explaining the cytoskeleton with animation

Workshop mentoring high-school students in fluorescence microscopy

Interactive AR app visualizing organelle ultrastructure

Citizen-science yeast mutagenesis project for protein folding

Harvard – PhD in Molecular & Cellular Biology

Visualize and reprogram the cell’s inner universe.

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