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Project Ideas for Doctor of Philosophy in Biostatistics and Bioinformatics

Statistical innovation powering omics, imaging, and precision medicine.

🏛 Introduction

The Duke PhD in Biostatistics & Bioinformatics trains algorithm-builders who translate massive biomedical datasets into actionable insight. Candidates develop Bayesian deep-learning models for single-cell RNA-seq, federated survival analysis for multi-site cancer trials, and causal graphs linking exposome to chronic disease. Interdisciplinary clinics pair scholars with physicians to push methods directly into patient care.

💡 Suggested Project Titles

Hierarchical model integrating eQTL and ATAC-seq for gene regulation inference

Differential-privacy survival analysis across hospital networks

Graph convolutional network predicting protein–drug interactions

Tensor factorization of spatial transcriptomics data

Causal mediation analysis of microbiome and obesity

Deep-learning harmonization of multi-vendor MRI scans

Synthetic-omics data generator for benchmark challenges

Interactive Shiny app visualizing variant pathogenicity

Policy brief on AI transparency in clinical decision support

Open-source Snakemake pipeline for single-cell QC and clustering

Bayesian nonparametric imputation of missing wearables data

Federated learning model predicting ICU sepsis onset

Blockchain ledger for reproducible bioinformatics workflows

VR data-storytelling exhibit of human cell atlas

Duke University – PhD in Biostatistics & Bioinformatics

Invent statistical tools that accelerate precision health at Duke.

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