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Project Ideas for Doctor of Philosophy in Computational Biology and Bioinformatics

Algorithms and AI unlocking biological complexity from genotypes to ecosystems.

🏛 Introduction

The Duke PhD in Computational Biology & Bioinformatics trains algorithm architects who turn omics torrents into biological insight. Students build graph neural networks that predict protein folding intermediates, engineer federated GWAS across hospital firewalls, and design causal AI that links exposome, microbiome, and phenome. Entrepreneurship sprints help transform pipelines into venture-backed diagnostics and agro-tech solutions.

💡 Suggested Project Titles

Transformer model integrating RNA velocity and ATAC-seq trajectories

Bayesian phylogenetics tracking zoonotic spillover events

Federated survival analysis for multi-site cancer trials

Causal mediation linking air pollution, epigenetics, and COPD

Quantum-computing prototype for protein–ligand docking

Spatial transcriptomics tensor factorization visualizer

Deep-fake detection of manipulated Western blot images

Blockchain ledger for sample provenance in multi-omics consortia

Synthetic-omics benchmark generator for ML competitions

VR atlas of chromatin 3-D architecture during differentiation

Public outreach MOOC on AI for genome medicine

Policy memo on genomic data privacy in cloud platforms

Open-source Snakemake pipeline for single-cell QC

Meta-analysis dashboard of CRISPR off-target datasets

Citizen-science smartphone microscope for biodiversity barcoding

Duke University – PhD in Computational Biology & Bioinformatics

Invent algorithms that accelerate life-science breakthroughs at Duke.

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