Duke’s Genetics & Genomics PhD trains investigators to decode genomes and translate cues into therapies. Students deploy long-read sequencing to map structural variation, engineer CRISPR base-editing therapies, and build pangenome graphs for under-represented ancestries. Partnerships with the Duke Clinical Genomics Center accelerate bench-to-bedside pipelines and policy briefs on genetic equity.
Pangenome assembly incorporating Indigenous North American genomes
Epigenome editing of hemoglobin switch for sickle-cell therapy
Graph-based variant caller reducing reference bias
Causal mediation of microbiome-host gene interactions in IBD
AI model predicting enhancer–promoter loops from Hi-C data
Long-read methylome profiling in neurodegeneration
Gene-drive safety switch modeling for malaria control
Blockchain consent platform for genomic data sharing
Public outreach game teaching inheritance patterns
Policy memo on insurance coverage for polygenic-risk testing
CRISPR screen for non-coding variants affecting adipogenesis
VR visualization of 3-D genome folding dynamics
Citizen-science saliva kit for global allelic diversity mapping
Open-source toolkit for ancestry-aware GWAS pipelines
Express barcoding workflow for field biodiversity surveys
Engineer equitable genome science with Duke’s transformative program.
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