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Project Ideas for Doctor of Philosophy in Molecular Genetics and Microbiology

Microbial genetics, pathogenesis, and microbiome engineering for global health.

🏛 Introduction

Duke’s Ph.D. in Molecular Genetics & Microbiology probes how microbes evolve, interact, and influence hosts. Trainees sequence pandemic-scale pathogen cohorts, build CRISPR antimicrobials, and program gut bacteria to secrete therapeutic peptides. Field collaboration with global health hubs turns lab discoveries into deployable diagnostics and phage therapies.

💡 Suggested Project Titles

Metagenomic survey of urban wastewater for AMR genes

Phage-display library targeting multidrug-resistant Pseudomonas

CRISPR-Cas13 antiviral against dengue RNA genome

Synthetic probiotic degrading phenylalanine in PKU model

Transposon-sequencing map of TB drug-tolerance networks

AI prediction of viral host-jump potential from spike proteins

Spatial transcriptomics of gut biofilm–immune crosstalk

Blockchain cold-chain ledger for live vaccine shipments

Citizen-science microbiome kit mapping indoor air diversity

Policy brief on wastewater surveillance for pandemic early warning

VR lab module showing phage infection cycles

Deep-learning classifier of plasmid transfer events

Bioreactor evolution of yeast for sustainable bioplastics

Open-source pipeline for microbial pangenome graphs

Duke University – PhD in Molecular Genetics & Microbiology

Harness microbes and mitigate pathogens with Duke’s MGM doctorate.

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