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Project Ideas for Doctor of Philosophy in Cell and Molecular Biology

From single molecules to cellular systems engineering.

🏛 Introduction

Duke’s cross-departmental PhD in Cell & Molecular Biology (CMB) empowers scholars to decipher and reprogram cellular machinery. Rotations span super-resolution imaging of mitotic spindle dynamics, CRISPR screens mapping ferroptosis regulators, and synthetic organelle engineering. Professional tracks support biotech translation, policy, or K-12 outreach.

💡 Suggested Project Titles

Optogenetic control of phase-separated transcriptional condensates

Proximity labeling proteomics identifying viral-host interactomes

Live-cell lattice light-sheet imaging of cytoskeletal repair

AI-enhanced cryo-ET segmentation of mitochondrial morphology

Synthetic lipid droplet bioreactor for metabolic engineering

Single-cell multi-omics of stress granule assembly

CRISPRa screen for senescence-protective pathways

Mathematical model of nuclear-pore transport kinetics

Nano-needle electroporation delivering mRNA therapeutics

Policy memo on gene-drive governance in vector control

Public science exhibit visualizing cell division in VR

Duke University – PhD in Cell & Molecular Biology

Engineer and understand life’s fundamental unit through Duke CMB.

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