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Project Ideas for Doctor of Philosophy in Medical Science

A translational research PhD bridging molecular science and clinical impact in human health.

🏛 Introduction

Ohio State’s PhD in Medical Science offers interdisciplinary research opportunities across cancer biology, immunology, neuroscience, pharmacology, and genetics. With strong connections to OSU’s Wexner Medical Center and NIH-funded labs, students conduct translational and biomedical research aimed at improving diagnostics, therapies, and patient outcomes. The program prepares future faculty, clinical scientists, and biotech innovators.

💡 Suggested Project Titles

CRISPR-mediated gene editing for correcting genetic mutations in hemoglobinopathies

Developing blood-based biomarkers for early-stage pancreatic cancer detection

Investigating microRNA networks in neurodegenerative disease progression

Epigenetic modulation of immune checkpoint expression in tumor microenvironments

Organoid modeling of drug resistance in colorectal cancer

Analyzing single-cell transcriptomic changes during T-cell activation

Designing nanoparticle delivery systems for targeted chemotherapy in glioblastoma

Metabolomic profiling of metabolic disorders using LC–MS

Identifying autoantibody signatures in systemic lupus erythematosus patients

Studying mitochondrial dysfunction in age-related macular degeneration

Mechanobiological modeling of bone remodeling under osteoporosis conditions

Longitudinal study of gut–brain axis signaling in Parkinson’s disease models

Development of biosensors for noninvasive glucose and lactate monitoring

Analyzing the role of gut microbiome diversity in post-antibiotic recovery

Characterizing inflammasome activation in infectious disease pathogenesis

Design of 3D-printed scaffolds for stem cell-based tissue regeneration

Neuroimaging–genetics correlations in cognitive decline trajectories

Evaluating antibody–drug conjugates in personalized oncology therapies

Developing machine learning classifiers for real-time pathology image recognition

Exploring prenatal environmental exposures and neurodevelopmental disorders

Ohio State – PhD in Medical Science

Advance biomedical discovery from lab to clinic with OSU’s Medical Science PhD.

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